Plasminogen activator inhibitor-1 (PAI-1) is a member of the serpin family that are involved in fibrinolysis and wound healing.
PAI-1 is therefore crucially involved in cardiovascular health, cancer and chronic health conditions. Measuring PAI-1 helps us to better understand risk of thrombosis and atherosclerosis in particular.
Sillen M and Declerck PJ (2020) Targeting PAI-1 in Cardiovascular Disease: Structural Insights Into PAI-1 Functionality and Inhibition. Front. Cardiovasc. Med. 7:622473. doi: 10.3389/fcvm.2020.622473
PAI genes encode the Serpine1 gene, which is positioned on chromosome 7. The 4G/5G is a common polymorphism